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Bioprinted Skeletal Muscle Tissue with a Perfusable Microchannel Network

Skeletal muscle tissue (SMT), the body’s largest organ by mass, plays a vital role in movement, posture, breathing, overall physiology and energy homeostasis. However, genetic disorders, diseases, injuries, and aging can impair this essential organ, significantly impacting health and quality of life. Traditional 3D culture systems have struggled to replicate the complex structure and functionality of native muscle tissue, particularly at larger, centimeter scales. Using advanced bioprinting technologies, Dr. Miriam Filippi and her group from the Soft Robotics Laboratory (led by Prof. Robert Katzschmann at ETH Zurich) have developed biohybrid SMT constructs that effectively mimic native muscle tissue.