Harvard Medical School Researchers Print Mechanically Robust Cartilage-like Tissue with the INKREDIBLE


Harvard Medical School

Research team

Bruna A. G. de Melo, Yasamin A. Jodat, Shreya Mehrotra, et al.


Osteoarthritis results in the damage or breakdown of joint cartilage between bones. Articular cartilage regeneration within the body is limited and currently is incurable. Development of implantable engineered cartilage that supports cyclic mechanical locomotion and normal chondrogenic behavior is greatly needed to enhance the quality of life for millions.


The researchers at Harvard Medical School combined hard and soft biomaterials along with stem cells on their INKREDIBLE to 3D bioprint mechanically robust 3D cartilage-like tissues.


The bioprinted cartilage like-tissues demonstrated high viability with normal chondrogenic behavior and the combination of biomaterials did not adversely affect the mechanical properties. It is suggested that the innovative dual material bioprinting approach is a significant step towards creating mechanically robust and viable bioengineered cartilage tissues on-demand.

Read more


Relevant products for this post

More Customer Spotlights

Researchers at Rensselaer Polytechnic Institute have developed a way to 3D print living skin, complete with blood vessels. The advancement, published online today in Tissue Engineering Part A, is a significant step toward creating grafts that are more like the skin our bodies produce naturally
Using human blood cells, Brazilian researchers have obtained hepatic organoids ("mini-livers") that perform all of the liver's typical functions, such as producing vital proteins, storing vitamins and secreting bile, among many others.
With the help of a BIO X printer, scientists in the Department of Applied Science and Technology validated the use of bioprinted collagen nanocomposites for high-resolution scaffolds, taking a significant step toward producing more biomimetic patient-specific bone-like scaffolds on demand. With millions affected by osteoporosis and degradation of bone mechanics such regenerative medicine strategies are urgently needed.
Bioengineers from Tufts University coupled the INKREDIBLE with a novel printing technique to achieve hierarchical assembly of silk fibroin molecules into 3D macroscale architectures that have intrinsic biocompatibility, as well as exceptional mechanical strength and shape complexity.