RIT researchers develop bioinks using CELLINK BIO X to promote organ regeneration

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Synopsis

Professor Iris Rivero’s research at RIT is looking into a variety of material combinations for the production of 3D bioprinted scaffolds to promote the growth of new, healthy tissue, for replacement in the body, or be incorporated into the design of medical implants.

Challenge

In order to promote cell function outside of the body and move closer towards tissue regeneration, a cell friendly environment is essential. This environment must be biocompatible and functionalized in a way to promote cells to develop in a manner that is natural and mimics what is found in the body. In the world of bioprinting this is usually dictated by the bioink used. Rivero’s group is looking to develop and test material combinations that will produce a bioink ideal to mimic natural bone and be able to go through the extrusion bioprinting process.

Solution

By using the BIO X the group can continue to develop and test a variety of biomaterials, ranging from biopolymers like PCL to materials like collagen, a protein that is abundant in our bodies. Currently the group is testing a combination of ceramic particles to a biopolymer, like PLA.

Results

The study demonstrated that rheological optimization of SA-GL hydrogel enhances printability and viability of NSCLC PDX and CAF co-cultures, allowing for 3D spheroid formation within the printed scaffold. The spheroids exhibited tumor-specific markers (such as vimentin and α-SMA), confirming cellular crosstalk. This model can be used for studying high-throughput drug screening and other preclinical applications.

Learn more

Hear about the group’s plan here:

BIO CELLX
BIO CELLX
See a video on how the system works in practice

Get the link to the full video below, or watch the abridged version on our Youtube channel.

BIO X6 - Demo

BIO X6 - Demo