Quantum X bio
3D microfabrication for biological and biomedical applications
2PP bioprinting - Creating the world's most accurate 3D bioprinter
Reimagining Nanoscribe’s Two-Photon Polymerization (2PP) printing technology through a biologist’s lens. It’s time to explore bioprinting on the nano- and microscale with the Quantum X bio.
Optimized for cellular work
A temperature-controlled environment in conjunction with onboard sterility measures makes the Quantum X bio the go-to system for exploring biological applications.
Smart, connected workflows
Ensure quality of your print job from start to finish through sensors and video data. Save time by controlling the system from the touchscreen or the desktop software.
Unprecedented accuracy
Intuitive software
With user-friendly software solutions and a library of proven bioprinting STL models, the Quantum X bio promises for an intuitive and straightforward set up.
Flexibility prioritized
Print virtually any 3D design with unmatched precision and speed on a wide range of substrates – including microscope slides and petri dishes.
Extensive biomaterial offerings
Choose between our tailored, functionalized biomaterials developed at Nanoscribe, CELLINK and Advanced BioMatrix, or from externally available photoresins.
Be prepared for live-cell printing
Quantum X bio provides all the features you need for printing with bioresins containing living cells – and keeping them alive. This allows you to explore exciting new applications like vascularized tissue printing, smart / living materials, topology for cell mechanics and migrations, sub-micron patterning and more.
- Open system compatible with any available bioresin
- Cell-friendly wavelength (780 nm)
- Sterile, temperature-controlled environment
- Cell viability >90% possible
3D structure containing living NIH 3T3 fibroblast cells, printed from a custom bioink based on Gelatin methacrylate. Cell viability one hour after printing is > 90% as obtained by live-dead staining.
Cultivate cells in 3D printed microwell arrays. Thanks to the use of biocompatible materials, the cells can attach and proliferate as seen in the fluorescent microscope image.
By 3D bioprinting complex microfluidic structures, vasculature models can be effectively fabricated. Here, the various circuits can be seen by flushing each structure with different colored fluids.
Due to the precise microfabrication technology, the Quantum X bio enables 3D printed drug delivery applications. The image demonstrates our technology’s ability to realize high aspect ratio.
Technical features
What is 2PP bioprinting?
2-photon polymerization (2PP) requires two photons to deliver the energy necessary to cause a photoreaction, and this only happens when two photons overlap in the same time and space (X, Y, and Z). The 2PP technique allows users to print into the photoresist which enables complex constructs to be printed without additional supports. Additionally, since two photons are required to trigger the photoreaction, the smallest feature size is confined to the volume where the two photons overlap, enabling submicron precision for the features!
Ready. Set. Print.
Organize and monitor your research project with our intuitive software and excellent data tracking. Generate, upload, print, and monitor your print job directly from the device’s touchscreen or remotely from your PC.
With Nanoscribe’s UX-optimized software solutions, inspired by a bioprinting library of proven STL models, and monitoring of sensor and video data during printing, it’s genuinely easy to achieve printing success.
Bioconvergence at its best
Benchmark scores
| Surface roughness | down to ≤ 5 nm |
| Minimum feature size¹ | down to 100 nm |
| Shape accuracy | down to ≤ 200 nm |
| Batch processing | up to 200 typical mesoscale structures over night |
| Autofocus precision | down to ≤ 30 nm |
| Print field diameter | 25 mm divided by lens magnification |
| Maximum scan speed ² | 6.25 m/s divided by lens magnification |
General system properties
| Printing technology | • Layer-by-layer 3D printing based on Two-Photon Polymerization (2PP) • Two-Photon Grayscale Lithography (2GL®) with voxel tuning capability |
| Substrates | • Microscope slides (3 x 1” / 76 x 26 mm) • Wafers 1” (25.4 mm) to 6” (150 mm) • Glass, silicon, and further transparent and opaque materials • Petri Dishes (35 or 50 mm) |
| Photoresins | • Advanced BioMatrix Hydrogels • Xpect-inx Bioinks • Nanoscribe IP-Photoresins (polymers) • Nanoscribe GP Photoresin (glass) • Customer User Materials |
| Maximum printing area | 50 x 50 mm² |
Given values may vary depending on the photoresin and structure geometry
¹ 100 nm feature size control in all spatial directions
² e.g. for 10x magnification: 625 mm/s
