3D Bioprinted Skeletal Muscles Integrated With Neural Cells to Accelerate Functional Regeneration

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have improved upon the 3D bioprinting technique they developed to engineer skeletal muscle as a potential therapy for replacing diseased or damaged muscle tissue, moving another step closer to someday being able to treat patients.

Skeletal muscles are attached to bones by tendons and are responsible for the body’s movement. When they are damaged, there is often loss of muscle function because the nerves are no longer sending signals to the brain.

Treatment of extensive muscle defect injuries like those caused by improvised explosive devices (IEDs) on the battlefield, for instance, is difficult and often requires reconstructive surgery with muscle grafts. Effective nerve integration of bioengineered skeletal muscle tissues has been a challenge.

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