BIO CELLX

Automated 3D Cell Culture. Simplified.
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Upscaled automation

The high-throughput, fully automated biodispensing solution that leverages BIOPOD (bioprinting on demand) technology with pre-set and pre-validated protocols to bring the power of 3D cell biology to your benchtop.
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Easy to operate
The platform leverages BIOPOD technology by combining a state-of-the-art instrument with pre-validated, built-in protocols and material mixing cartridges to offer a solution that is easier to use than any other system on the market: a plug-and-play user experience.
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Automated bioink preparation
Cartridges enable the automated mixing of cells with hydrogels gently and homogenously at the push of a button. This novel approach ensures high cell viability and automates neutralizing collagen.
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Effortless hydrogel extrusion
Each of the three cartridge stations offers precise temperature control ranging from 0°C to 60°C, allowing for hassle-free printing of ECM hydrogels and bioinks like Collagen, GelMA, and GelXA.
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Precise and reproducible
A high-precision positive displacement extrusion system provides reproducible results every single time, regardless of the dispensed material.
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Droplet
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Grid
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By scientists, for scientists

Pre-validated protocols for easy use

Working with pre-validated protocols allows you to produce 3D cellular models with minimal effort. The pre-loaded detailed plans cover everything from construct geometry to biomaterial selection to dispensing settings. Additionally, each protocol includes step-by-step instructions for upstream and downstream analysis, so there are no bottlenecks in your workflow as you transition to 3D cell culturing.

Select from protocols pre-loaded on your system or from an ever-growing database of protocols offered as cloud-based updates.
Benefits
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High
reproducibility
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High cellular viability
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High
throughput
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Better downstream imaging
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High
throughput
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Cost
effective
Time-speed-desk
Time
savings
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Better downstream imaging

Designed for your success

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Pre-validated protocols
Developed by scientists for scientists, pre-validated protocols ensure consistent and reproducible 3D model generation, guiding users through every step of the workflow, from material selection to dispensing to suggested downstream analysis methods.
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High-throughput solution
By supporting microplates up to 384-well plates, the platform offers a perfect solution for drug discovery applications. ​
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Sterility uncompromised
CELLINK’s fully enclosed, proprietary Clean Chamber technology, combined with a patent pending de-lidding solution, ensures the sterility of the entire workflow when working on a benchtop in a laboratory environment.
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High accuracy automated calibration​
Ensures reproducible prints thanks to industry-leading auto calibration, which leverages a suite of sensors to accurately position nozzles for consistently optimal dispensing. ​
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Nozzle auto-priming system
A patent pending system activates when the camera points at the nozzle tip, triggering an algorithm to automatically prime the nozzle ensuring the right droplet size.
From bioprinting to biodispensing

Further reducing the barriers to 3D cell culture for reproducible and fully automated workflows

Whereas bioprinters produce complex models, biodispensers create simpler models and droplets while greatly increasing throughput.

Biodispensing makes the creation of biomimetic models accessible to everyone. By focusing on droplets and simpler geometries, it ensures reproducibility and increases the speed at which models are created. Furthermore, biodispensing requires much less input from the user, allowing for an unparalleled plug-and-play experience.

Models

Features

Materials

Biodispensing at the push of a button

BIO CELLX Studio

Maximizing walk-away capabilities through the power of automation.
A brand-new intuitive version of DNA Studio guides users through the entire process, from setting up the system to selecting one of the pre-set and pre-validated protocols. ​
No training required.
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No code solution
An intuitive user interface requires no prior coding experience​
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No modeling required
Built-in 3D models mean no time wasted in CAD software.
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Touchscreen optimized
It has never been easier to operate an interface with a gloved finger.
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Flexible well selection
Selecting single wells or columns in a plate is as easy as swiping a finger.
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From one to thousands of samples
The interface will guide you through the process of filling multiple plates.
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Customer profiles
Integration with MyCELLINK account allows the protocols to be used on multiple instruments.
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Adjustable droplet size
Select the size of droplets in line with your goals and downstream analysis methods.
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Camera view
Observe the samples as they get dispensed.

Click to see the system in action

Maximizing walk-away capabilities through the power of automation

1.
Protocol selection
2.
Cell type selection
A bio-convergence workflow

Developing the next generation of cancer therapeutics

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1. Cell counting
Kick-start your 3D cell culture workflow by ensuring cell health and density. The CASY cell counter, distributed by CYTENA, can be used to assess cell viability in a label-free method with as little as 10 μL.
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2. 3D model generation
Effortlessly mix cells into tailored biomaterials like TeloCol-10 (bovine collagen) provided by Advanced BioMatrix with full integration with the BIO CELLX. Begin 3D model generation with the click of a button thanks to the intuitive BIOPOD technology onboard.
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3. Plate washer
Ensure ideal cell culture conditions with automated media exchange thanks to CYTENA’s C.WASH system. Remove old media and directly dispense fresh media all while eliminating the risk of contamination.​
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4. Compound dispensing
Begin high-throughput screening by rapidly dispensing different concentrations of drugs and reagents using DISPENDIX’s I.DOT, the premier non-contact liquid handler.
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5. Assays and analysis
Harness the power of live cell imaging with CYTENA’s CELLCYTE X. Gather essential insights on cell health, cell count, nuclei count all from inside an incubator. Multiplex your assays by adding cell-friendly reagents like C.LIVE Tox and understand parameters like metabolic activity, apoptosis, and membrane integrity.

Technical specifications

Build volume, mm
125x85x38​
Build surface compatibility​
Multi-well plates 6-well to 384-well, Petri dishes​
Resolution XY, µm
3
Layer resolution, µm
1.5
No. of cartridge stations
3
Source fluid temperature range, °C
0-60
Volume unit step, µL​
0.1​
Printbed temperature range, °C​
0-60​
Photocuring system, nm​
365, 405, 485, 520​
Calibration​
Automatic
User interface​
Tablet​

A new standard in cell culture