Got collagen?

A primer on finding the right collagen for your research.

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Being the most abundant protein in mammals has earned collagen a special status in tissue engineering labs. But recent global supply chain disruptions have made finding a reliable supplier a truly Herculean race against time. Thankfully, Advanced BioMatrix and CELLINK offer over 30 collagen I products, and our well-oiled pipeline is optimized to minimize disruptions to your research. Here’s a quick cheat sheet on the essentials of collagen hydrogels and where to find more resources

The most common collagen types for bioengineering

With 28 collagens having been identified in vertebrates, finding the right collagen for your research might feel as daunting as choosing one bag in the entire grocery aisle dedicated to potato chips. Advanced BioMatrix and CELLINK sell more than 30 collagen I products, making us the world’s largest supplier of collagen I. We also offer types II, III and IV. Here’s a breakdown of the tissue engineering applications for all four 

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  Applications  Derivations Availability 
Type I  Collagen All tissues and organs  Bovine, rat, human   Solution, powder, sponge, EZ Gel, lyophilized, UV crosslinkable (over 30 products) 
Type II Collagen Cartilage, vitreous humor of the eye  Bovine  Sterile solution 
Type III Collagen Skin, blood vessels, other organs  Human  Powder, solution 
Type IV Collagen Extracellular basement membranes  Human  Powder, lyophilized powder

What is collagen I?

In short, collagen I is a major structural component of skin, bone, tendon, and other connective tissues. A defining property is that it forms fibrous networks that enhance the structural integrity of the extracellular matrix (ECM) and promote cell adhesion, growth and tissue morphogenesis. Tissue engineers often grow cells inside collagen hydrogels to better replicate the in vivo environment of specific tissues.

Running low?

Reach out to our biomaterial specialists, who will be happy to recommend the right products for your unique research needs.

Contact us at sales@cellink.com.

What are the different types of collagen I extractions?

Atelocollagen

Collagen extracted with enzymes maintains the triple-helix construction but cleaves the telopeptide regions.

telocollagen

Collagen extracted with acid maintains the triple helix and leaves the telopeptide regions intact.

In the end, telocollagens achieve gelation quicker and produce a stronger hydrogel than atelocollagens of the same concentration.

Have questions?

Don’t miss this informative video complete with rheological data on the stiffness of atelocollagen vs telocollagen. Watch video.

Does collagen I concentration matter?

Collagen formulations with a higher concentration tend to gel quicker and form stronger, stiffer hydrogels. Stiffer hydrogels contribute to the structural integrity of a construct, which is of particular importance when it comes to load-bearing scenarios such as bone tissue engineering. Plus, hydrogel stiffness, like ECM stiffness, impacts a wide variety of cellular pathways, including propagation, differentiation, lineage specification, gene expression, morphology, self-renewal, pluripotency and migration. Using collagen hydrogels with stiffnesses similar to native tissue is critically important, and these can be fine-tuned by controlling the collagen concentration.

Did you know?

Industry-leading standards

Read all about the rigorous testing used at CELLINK and Advanced BioMatrix to ensure >99% purity with our collagen I hydrogels.

Go More In-depth

Download this informative ebrochure on collagen I stiffness.

OVer 35 FAQ videos

Explore a trove of informative videos about collagen on Advanced BioMatrix’s YouTube channel.

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