More Relevant 3D Lung Cancer Models

Share on facebook
Share on twitter
Share on linkedin

To study the complexities of lung cancer, the leading cause of cancer-related deaths, and the mechanisms that drive metastasis, more physiologically relevant in vitro models are needed. 

We introduce a method to 3D bioprint in vitro lung models using A549 lung cancer cells embedded in gelatin methacrylate (GelMA) or Matrigel. After bioprinting with CELLINK’s BIO X™ and 14 days of cell culturing, we observed excellent tumor spheroid formation and physiologically relevant expression of β-catenin in 3D microenvironments. This lung disease model fabrication method can be used as a tool for automated assays in conjunction with high-throughput screening for drug development.

Application note

Explore how well the A549 cells clustered and formed spheroids naturally when cultured in 3D versus the flat morphology of the single cells cultured in 2D.

More from Our Blog

Got collagen?

Being the most abundant protein in mammals has earned collagen a special status in tissue engineering labs. But recent global supply chain disruptions have made finding a reliable supplier a truly Herculean race against time.

Read More

What are spheroids and why are they important?

Share on facebook Share on twitter Share on linkedin Spheroids, the three-dimensional (3D) cell cultures that arrange themselves during proliferation into sphere-like formations, got their name in the 1970s, when scientists observed

Read More

More efficient drug screening with 3D bioprinting

Share on facebook Share on twitter Share on linkedin Taking a drug to market is a competitive, costly and challenging process involving preclinical laboratory and animal testing before the even more time-consuming and expensive four

Read More
See a video on how the system works in practice

Get the link to the full video below, or watch the abridged version on our Youtube channel.

BIO X6 - Demo

BIO X6 - Demo