Stiffness Modulation of GelMA-based Bioinks for Biofabrication of Tissue Models
A bioink’s ability to mimic the mechanical and biological properties of native tissues is crucial for the success of 3D bioprinted constructs. In particular, stiffness plays a key role in influencing cellular behaviors such as adhesion, proliferation, and differentiation.
In this study, we investigated how the stiffness of GelMA-based bioinks can be modulated by adjusting key parameters:
- the degree of substitution (DS)
- polymer and photoinitiator concentration
- photocrosslinking conditions such as temperature, time, and irradiance.
