Stiffness Modulation of GelMA-based Bioinks for Biofabrication of Tissue Models

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A bioink’s ability to mimic the mechanical and biological properties of native tissues is crucial for the success of 3D bioprinted constructs. In particular, stiffness plays a key role in influencing cellular behaviors such as adhesion, proliferation, and differentiation.

 

In this study, we investigated how the stiffness of GelMA-based bioinks can be modulated by adjusting key parameters:

 

  • the degree of substitution (DS)
  • polymer and photoinitiator concentration
  • photocrosslinking conditions such as temperature, time, and irradiance.

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