BIO X™
The go-to 3D bioprinter for cell biologists, tissue engineers and biomedical researchers.
Unparalleled bioprinting experience
Explore the most user-friendly and flexible bioprinter in the world.
Unparalleled bioprinting experience
Explore the most user-friendly and flexible bioprinter in the world.
Limitless possibilities
BIO X is the first 3D bioprinter in the world with Intelligent Printheads (iPH), ensuring your research is always at the forefront.
Limitless possibilities
BIO X is the first 3D bioprinter in the world with Intelligent Printheads (iPH), ensuring your research is always at the forefront.
With an ever-growing list of Intelligent Printheads, the possibilities are limitless, giving you more freedom to push your research further.
Designed to Do More
The BIO X’s exceptional features maximize versatility to enhance your success in the following application areas and beyond.
Advanced Functionality and Versatility
The BIO X’s compatibility with virtually any material makes it the bioprinter of choice for industry leaders at the forefront of today’s biggest scientific breakthroughs. Whether you are automating 3D cell cultures, developing complex tissue constructs or testing new drug compounds, the BIO X has the advanced functionality and versatility to streamline workflows in a wide range of application areas.
Publications
Groundbreaking research made using BIO X.
Push the Limits
Bioprint with a wider range of materials and cell types thanks to precise printhead and printbed temperature control.
Push the Limits
Bioprint with a wider range of materials and cell types thanks to precise printhead and printbed temperature control.
With a printhead temperature range of 4°C to 250°C and a printbed temperature range between 4°C and 65°C, enjoy precise control of temperatures when working with temperature-sensitive materials like collagen and gelatin. The possibilities are limitless when you are able to work with a wider range of materials and cell types.
Enhanced Precision
The BIO X comes standard with motors of a 1 µm resolution, ensuring you can control the finest movements.
EXPLORE BIO X6™
The next generation bioprinter with 6 printheads allows the use of several crosslinking modalitites and multimaterial constructs simultaneously, enabling even more complex models.
Universal Compatibility
The BIO X’s open material platform is designed to give you the ability to bioprint with the widest range of materials.
Universal Compatibility
The BIO X’s open material platform is designed to give you the ability to bioprint with the widest range of materials.
We offer an extensive portfolio of bioinks but understand the importance of material development, which is why we built the BIO X to be an open system that is compatible with the widest range of materials available. Start developing your own bioinks with our high-quality bioink development products or explore our ready-to-print bioinks.
Patented Clean Chamber for Better Cell Safety
Built-in UV sterilization and a HEPA filter bring the sterility of the biosafety cabinet to the benchtop.
Clean Chamber for Better Cell Viability
Built-in UV sterilization and HEPA filters bring the sterility of the biosafety cabinet to the benchtop.
Dual high-powered fans channel air through a HEPA H14 filter to remove 99.995% of unwanted particles and microorganisms as part of the Clean Chamber™ technology, which also includes UV-C germicidal lights, rounded edges and positive air pressure. Initiate Clean Chamber before beginning your experiment to ensure full sterility around the print area for the duration of the print.
User-centered Design
Auto calibrate the printer directly from the touchscreen for added efficiency, even while wearing gloves.
User-centered Design
Auto calibrate the printer directly from the touchscreen for added efficiency.
Maximum Convenience
With onboard or desktop software options, a built-in compressor and auto calibration, the BIO X is ready to use right out the box.
Maximum Convenience
Onboard or desktop software options, built-in compressor and auto calibration.
Application Notes
Written by scientists for scientists, these papers highlight novel ways to optimize one’s research with the BIO X Bioprinter.
Alginate is a commonly used natural biomaterial in tissue engineering and is used extensively as a hydrogel for cell encapsulation and bioactive-delivery systems. The BIO X 3D bioprinter enables rapid and automated alginate bead encapsulations using either the Syringe Pump Printhead or the Electromagnetic Droplet Printhead for customized milli- to micro-meter diameter spherical encapsulations. Bioprinting | BIO X
Printing Alginate Beads: A Technical Note
Bioprinting | BIO X
Alginate is a commonly used natural biomaterial in tissue engineering and is used extensively as a hydrogel for cell encapsulation and bioactive-delivery systems. The BIO X 3D bioprinter enables rapid and automated alginate bead encapsulations using either the Syringe Pump Printhead or the Electromagnetic Droplet Printhead for customized milli- to micro-meter diameter spherical encapsulations.
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In this study, human lung cancer cells were cultured on 2D polystyrene plates and in 3D bioprinted gelatin methacrylate (GelMA) and Matrigel for 14 days to observe spheroid formation, cell morphology and junctional proteins. Bioprinting | Cancer research | BIO X
In Vitro 3D Lung Cancer Model Presents a More Relevant Expression of Junctional Proteins than 2D Cultures (English)
Bioprinting | Cancer research | BIO X
In this study, human lung cancer cells were cultured on 2D polystyrene plates and in 3D bioprinted gelatin methacrylate (GelMA) and Matrigel for 14 days to observe spheroid formation, cell morphology and junctional proteins.
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A co-culture of human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs) and a monoculture of induced pluripotent stem cells (iPSCs) were separately embedded in a selection of biomaterials for 7 days. Bioprinting | BIO X
Advanced In Vitro 3D Models to Investigate iPSC Pluripotency and Capillary Network Formation of HUVECs (English)
Bioprinting | BIO X
A co-culture of human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs) and a monoculture of induced pluripotent stem cells (iPSCs) were separately embedded in a selection of biomaterials for 7 days.
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In this study, a full thickness skin tissue model was bioprinted using the BIO X. The dermis was bioprinted using primary
dermal fibroblasts embedded in GelXA SKIN bioink, and the epidermis, containing a high concentration of
keratinocytes embedded in ColMA, was deposited on top of the dermis. Bioprinting | BIO X
3D Bioprinting Skin Tissue Models Using Primary Cells
Bioprinting | BIO X
In this study, a full thickness skin tissue model was bioprinted using the BIO X. The dermis was bioprinted using primary
dermal fibroblasts embedded in GelXA SKIN bioink, and the epidermis, containing a high concentration of
keratinocytes embedded in ColMA, was deposited on top of the dermis.
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Bioprinting mini liver models for hepatotoxicity studies using a novel method of “droplet in droplet” encapsulation on the BIO X. BIO X | Drug screening
Evaluating Liver Toxicity in Bioprinted Mini Livers
BIO X | Drug screening
Bioprinting mini liver models for hepatotoxicity studies using a novel method of “droplet in droplet” encapsulation on the BIO X.
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Using the BIO X to evaluate drug efficacy in aggressive forms of breast and pancreatic cancer in 2D cell cultures vs. 3D bioprinted tumor models. Cancer research | BIO X
Comparing Drug Response in 2D Cultures and 3D Bioprinted Tumoroids
Cancer research | BIO X
Using the BIO X to evaluate drug efficacy in aggressive forms of breast and pancreatic cancer in 2D cell cultures vs. 3D bioprinted tumor models.
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3D bioprinting a syngeneic tumor model of murine lung cancer on the BIO X to evaluate an immune checkpoint inhibitor (PD-1) in a 3D T cell cytotoxicity assay. Cancer research | BIO X
3D Bioprinted Tumor Model for Immuno-oncology Applications
Cancer research | BIO X
3D bioprinting a syngeneic tumor model of murine lung cancer on the BIO X to evaluate an immune checkpoint inhibitor (PD-1) in a 3D T cell cytotoxicity assay.
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| Technical Data | |
| Outer dimensions (L*W*H), mm | 477x441x365 |
| Weight, kg | 18 |
| Build Volume, mm |
130 x 90 x 70 mm
|
| Build surface compatibility | Multi-well plates, petridishes, glass slides |
| Resolution XY, μm | 1 |
| Layer Resolution, μm | 1 |
| Pressure range (internal pump), kPa | 0-200 |
| Pressure range (external air supply), kPa | 0-700 |
| No. of printhead slots | 3 |
| Photocuring sources (built-in), nm | 365, 405 |
| Printbed temperature range, °C | 4-65 |
| Printhead temperature range, °C | 4-250 (printhead specific) |
| Filter class, chamber air-flow | HEPA 14 |
| UV-sterilization | UV-C (275nm), 20mW output |
| Calibration Options | Manual and Automatic |
| User Interface | Integrated Display, DNA Studio |
| DNA Studio OS compatibility | Windows, Mac OS |
| Connectivity | USB Storage, Ethernet connection |
| Supported file formats, software | .gcode, .stl |