Ronawk T-blocks are disrupting the industry by enabling the production of adult stem cells in large quantities.
The study of adult stem cells has increased exponentially because of recent technological innovations in the life sciences, especially within the field of bioprinting. The array of applications under consideration runs the gamut—from reversing baldness to managing diabetes to transplanting personalized bioprinted organoids. With the latter, researchers are envisioning culturing a patient’s own adult stem cells to create viable organoids that could be transplanted into the patient with no need for the long-term immunosuppressant drugs they would have taken with a donated organ.
One of the obstacles that has stymied researchers is how difficult it is to locate adult stem cells from bone marrow, brain, muscle or fat tissues, not to mention trying to extract them in the quantities realistically needed for clinical use. As a result, many researchers have been working doggedly to find ways to generate adult stem cells in mass quantities with in vitro cell culturing.
Enter Ronawk’s T-block. The startup, which was spun off from labs at the University of Kansas Medical Center, used biocompatible hydrogels and a unique geometry to design the interlocking 3D cell culturing scaffolds. The T-block constructs can be seeded with adult stem cells, giving them the proper environment to proliferate outside the body in greater numbers. Researchers had also been unable to keep extracted adult stem cells viable for long periods of time. With their modular design, additional T-blocks can be added in the X, Y, Z axial directions indefinitely with no need for passaging, enabling cells to continue proliferating, migrating, secreting extracellular matrices and maturing into tissue.
Dr. Mellott characterizes the relationship with CELLINK less like one of traditional customer support and more of a collaboration. While experimenting with prototypes on the BIO X, he says, the suggestion from the company’s application scientists to experiment with options from the wide array of interchangeable printheads and toolheads was invaluable. Then, he was introduced to the digital light processing (DLP) Lumen X bioprinter (the previous iteration of the Lumen X+™), which allowed for production on a much larger scale as well as more precision. Furthermore, after the Kansas lab customized a platform to accommodate the extra printing area needed for the T-blocks, it was the CELLINK team who devised a workaround for handling the bigger files.
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