Evaluating Liver Toxicity in Bioprinted Mini Livers

To accurately and reproducibly predict drug-induced liver injury (DILI) in humans, in vitro 3D liver models can replace costly and low-throughput 2D cell culture systems, animal studies or lab-on-a-chip models. The new method of “droplet in droplet” (DID) bioprinting uses the BIO X to droplet-print hepatic (HepG2 and LX2) and non-hepatic (HUVEC) cells encapsulated in type I collagen. After 7 days of culture, these mini livers demonstrated cytotoxic responses to drugs, further validating 3D bioprinting as a viable high-throughput solution for modeling hepatic tissue and screening idiosyncratic drug reactions.

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BIO CELLX
BIO CELLX
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BIO X6 - Demo

BIO X6 - Demo