Traumatic brain injury (TBI) is a leading cause of death and long-term disability around the world. Numerous animal models have demonstrated BBB dysfunction following TBI. This perfusable 3D microvascular model offers the complex cytoarchitecture and multicellular arrangement that is seen in vivo. Coupled to a device that can deliver a mechanical insult, this system allows for the study of TBI pathology and therapeutic testing.
- Blood brain barrier dysfunction associated with Triatic Brain Injury (TBI)
- 3D bioprinting of perfusable brain microvessels and the generatin of fully endothelialized perfusable brain vasculature.
- Strategies on 3D cell culture
- Mechanical strain injury on 3D brain microvessels for TBI