Quantum X bio

3D microfabrication for biological and biomedical applications

World-leading precision and accuracy with 2PP bioprinting

CELLINK and Nanoscribe have reimagined two-photon polymerization (2PP) printing technology through a biologist’s lens. With Quantum X bio, you will explore bioprinting on the nano- and microscale.

Bringing your ideas to life

With Quantum X bio, we’re bringing the next level of 3D bioprinting
across all scales, from the subcellular to millimeters; whether printing’ on cell culture dishes, microscope slides or directly inside microfluidic chips. Hard acrylates, soft synthetics, natural bioresins and custom photoresins. The world is your playground across all dimensions.

Optimized for cellular printing

A temperature-controlled environment in conjunction with onboard sterility measures makes the Quantum X bio the go-to system for exploring biological applications.

2PP brings unprecedented accuracy

With 2PP bioprinting, you unlock high-performance 3D bioprinting with feature resolution down to 100nm on areas up to 25 cm².

A flexible and intuitive software solution

With user-friendly software solutions and a library of proven bioprinting STL models, the Quantum X bio promises for an intuitive and straightforward set up.

Sensors and video to keep quality on lock

Ensure quality of your print job from start to finish through sensors and video data. Save time by controlling the system from the touchscreen or the desktop software.

Extensive biomaterial offerings

Choose between our functionalized biomaterials developed at Nanoscribe, CELLINK and Advanced BioMatrix, or from externally available photoresins.

Game-changing bioprinting chamber

The chamber creates temperature and humidity controlled conditions, and a HEPA-filtered airflow with optional connections for pre-mixed air/CO2.

In-chip printing

MICROFLUIDICS MEET CELL CULTURE

Quantum X bio is a powerful 3D Microfabrication system that provides the flexibility and capabilities to print on a variety of substrates, including microfluidic systems for organ- or lab-on-a-chip applications. With these capabilities, microfluidics meets cell culture, enabling the creation of organoids.

Printing into microfluidic systems, including custom microfluidic channels and commercial microfluidic chips
Enabled by Dip-in Laser Lithography (DiLL)
Highly precise positioning of the prints within microfluidic systems
High aspect ratio and high structures can be printed into open microfluidic channels and wells
Touchscreen tap-to-align feature to easily set the print position within the channel or well
Open system for custom resins, such as degradable materials
Standard 3D designs available in Bioprinting Model Library

Be prepared for live-cell printing

Quantum X bio provides all the features you need for printing with bioresins containing living cells – and keeping them alive. This allows you to explore exciting new applications like vascularized tissue printing, smart / living materials, topology for cell mechanics and migrations, sub-micron patterning and more.

Cultivate cells in 3D

Cultivate cells in 3D printed microwell arrays. Thanks to the use of biocompatible materials, the cells can attach and proliferate as seen in the fluorescent microscope image.

3D printed drug delivery

Due to the precise microfabrication technology, the Quantum X bio enables 3D printed drug delivery applications. The image demonstrates our technology’s ability to realize high aspect ratio.

And more applications

What is 2PP bioprinting?

2-photon polymerization (2PP) requires two photons to deliver the energy necessary to cause a photoreaction, and this only happens when two photons overlap in the same time and space (X, Y, and Z). The 2PP technique allows users to print into the photoresist which enables complex constructs to be printed without additional supports. Additionally, since two photons are required to trigger the photoreaction, the smallest feature size is confined to the volume where the two photons overlap, enabling submicron precision for the features!

SOFTWARE

Ready. Set. Print.

Organize and monitor your research project with our intuitive software and excellent data tracking. Generate, upload, print, and monitor your print job directly from the device’s touchscreen or remotely from your PC.

With Nanoscribe’s UX-optimized software solutions, inspired by a bioprinting library of proven STL models, and monitoring of sensor and video data during printing, it’s genuinely easy to achieve printing success.

Technical Specifications

BENCHMARK SCORES

Minimum feature size¹	down to 100 nm
Stitching-free part diameter	up to 4000 µm
Live-cell printing viability	> 90%
Maximum scan speed²	6.25 m/s divided by lens magnification

GENERAL SYSTEM PROPERTIES

Printing technology	Layer-by-layer 3D printing based on Two-Photon Polymerization (2PP) Upright platform with Dip-in Laser Lithography (DiLL)
Substrates	Microscope slides / microfluidic chips (3 x 1” / 76 x 26 mm) Wafers 1” (25.4 mm) to 6” (150 mm) Glass, silicon, and further transparent and opaque materials, and coated/uncoated substrates Cell culture imaging dishes (35 mm or 50 mm)
Photoresins	Open system for custom materials Hydrogels/Bioresins from Advanced BioMatrix, CELLINK and BIO INX Nanoscribe IP/IPX Photoresins (polymers) Nanoscribe acrylate, PDMS and glass photoresins (biocompatible, ISO 10993-5)
Maximum printing area	50 x 50 mm²

Given values may vary depending on the photoresin and structure geometry
¹ 100 nm feature size control in x/y direction, valid only for certain photopolymers
² e.g. for 10x magnification: 625 mm/s

Bioconvergence at its best

Powered by NANOSCRIBE’s proprietary Two-Photon Grayscale Lithography (2GL®) technology and CELLINK’s award-winning cell-friendly technologies, the Quantum X bio high-precision 3D microfabrication bioprinter is the first of its kind. 2GL has been customized and reimagined with the cell biologist and tissue engineer in mind. Microfabrication speed and precision meet patented Clean Chamber sterilization, advanced temperature controls and biocompatibility to create the fastest and most precise tool on the market for vasculature printing with excellent shape accuracy.

The Quantum X bio promises to accelerate innovation across critical applications like tissue engineering, cell biology and regenerative medicine.

Are you ready to create the future of health?

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