3D bioprinting of liver mimetic models with regionally varied stiffness
Bioprinted constructs with tunable stiffness and mechanical properties are highly desired to recapitulate the native tissue environment with heterogeneous stiffness. In this app note, we detail how to bioprint multi-stiffness liver constructs with physiologically relevant microarchitectures using the BIONOVA X. We also go and how these biomimetic constructs can enable advanced disease modelling and investigate the proliferation, growth, and migration of cells in micro-environments with various mechanical properties.
Learn more about:
- Mechanical properties like stiffness can upregulate biomarkers to match in vivo conditions
- Grayscale bioprinting can be utilized to develop multi-stiffness constructs
- Combining materials functional biomaterial elements such as decellularized extracellular matrix (dECM), with photopolymerizable bioinks to better mimic the native tissue environment.
