Biomaterials science and biomedical engineering have sustained as one among frontier and growing areas of research and innovation within the engineering science community in the world; considering the number of scientific discoveries and their societal impact. Significant attempts were largely directed to re-create functional musculoskeletal systems with considerable potential to treat various types of human diseases. At the beginning of my presentation, I will present multiscale measurements and analysis to quantitatively understand the process physics of binderjet 3D printing. I will present some of our recent results to demonstrate the efficacy of the 3D powder printing to fabricate Sr-substituted Mg-phosphate bioceramic scaffolds and Zirconia bioceramics, albeit with specific challenges. A major emphasis will be placed on the binder formulation, post-processing treatment, and micro-computed tomography of interconnected porous architecture together with the strength reliability. One of the most recent clinical translational attempts to treat decompressive craniectomy using 3D powder printed patient-specific cranial prosthesis will be presented. Towards the end, the recent results of 3D bioprinting will be presented. It will be shown as how the hydrothermally synthesized nanocrystalline needle-shaped HAp particles (<30 nm) were incorporated into pre-crosslinked gelatin methacryloyl (GelMA) hydrogel to obtain a better combination of compression strength (~ 300 kPa) and elastic modulus (~ 300 kPa) in a designed scaffold. We propose that the inorganic-organic nanocomposite hydrogel could be efficiently assembled to formulate a potential bioink for 3D bioprinting applications towards bone tissue regeneration. This lecture will close by introducing a new concept, Biomaterialomics, which brings together Biomaterials science and Data Science.
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In the realm of tissue engineering, 3D bioprinting stands out as a revolutionary technology with immense potential. By allowing precise printing and patterning of cells and matrix materials in three dimensions, 3D bioprinting enables the recreation of tissue structures that closely mimic their natural counterparts. This capability holds the promise of generating tissue-mimetic constructs capable of replicating the functions of specific tissues within the body.
At our lab, we’ve been exploring a biomimetic approach to 3D bioprinting, which involves mimicking the intricate structure and organization of native tissues. One key aspect of our approach is the utilization of decellularized tissue matrix bioink, which provides a natural scaffold rich in extracellular matrix components necessary for cell adhesion, proliferation, and differentiation.
During my talk, I will delve into the various modalities of bioprinting, each with its unique mechanisms and operations. By discussing the differences between these modalities, attendees will gain a comprehensive understanding of the bioprinting landscape and the specific advantages each technique offers.
Furthermore, I’ll share insights into our ongoing research projects at the lab, particularly focusing on our use of extrusion-based 3D bioprinting. This method allows for precise deposition of bioink materials, enabling the creation of complex tissue constructs with tailored properties.
Moreover, I’ll highlight some of our translational works that are progressing toward clinical trials. These projects represent the culmination of our efforts to bridge the gap between cutting-edge research and real-world applications, with the ultimate goal of developing novel tissue-engineered therapies to address clinical needs.
Join us for an exciting session of Bioprinting Ignited, where two speakers will be selected from the Abstract Submissions, to inspire us with their research. Submit your abstract here to be considered.
Cecilia Edebo, CELLINK CEO
Our CEO, Cecilia Edebo, will be welcoming you to our CELLINK Partnership Conference 2023.
New materials and manufacturing techniques are emerging with potential to address the challenges associated with the manufacture of pharmaceutical systems that will teach new tricks to old drugs. 3D printing / bioprinting is a technique that can used for the manufacturing of dosage forms and medical implants, and offers a new paradigm for the direct manufacture of personalized dosage forms. The introduction of the fourth dimension has led to an increase in the degree of complexity and customization possibilities of such personalized medical implants. However, 4D printing is still in the early stages, thus research is needed to prove its feasibility in healthcare applications. This talk will provide an overview of current approaches from our research Lab, towards the manufacturing of drug delivery systems and medical devices.
In 2022, the groundbreaking milestone of implanting 3D-bioprinted human tissue in patients was achieved, marking a significant shift in focus from “can we” to “when can we” translate bioengineered tissues and organs into clinical settings. However, substantial challenges remain in the path towards achieving widespread clinical translation.
Join us for this insightful discussion as experts discuss the challenges, considerations, regulations and trends in 3D bioprinting for biomedical applications allowing us to move one step closer to preclinical and clinical translations.
At Carcinotech our technology offers drug discovery and oncologists the opportunity to test multiple drug responses, doses, time points etc from a defined patient(s) population. Carcino3D™ technology is validated to ensure consistency, high-throughput and robust results. Using patient biopsies, tissue engineering, advanced robotic manufacturing and quality control to produce highly predictive, assay-ready printed tumours at significant throughput. This provides our clients with a “clinical biopsy” quality model, using isolated patient-specific cells and representing donor specific cancer heterogeneity. These printed tumours can be delivered assay-ready to your lab or our team of 3D oncology experts can utilise them to offer therapeutic screening services.
This is the session to advance your g-code script skills. The session will touch on non-planar g-code, what it is and how to implement it in your script. We will also dive into how to write script for very specific movements, tool head specific commands and how to use pp g-code as a tool to fabricate more advanced print patterns.
Level: Advanced
Join us for an inspiring session of Bioprinting Ignited, celebrating achievements and breakthroughs of rising pioneers in the field of bioprinting. This session features the following presentations:
Generation of a Perfusable 3D Lung Cancer Model by Digital Light Processing
Yikun Mei, Technische Universität Berlin
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A comparative study on the suitability of bioinks for 3D bioprinted head and neck tumour model
Alexya Azhakesan, Medical Faculty of Mannheim University of Heidelberg
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3D Bioprinted Vascularized Skin-on-a-Chip Model for Drug Testing and Wound Healing Studies
Federico Maggiotto, University of Padua
This is the workshop session to deepen your light-based bioprinting skills. Learn how to design models for your Lumen X or BIONOVA X bioprinter and how to adapt the light parameters for optimal print quality. We will dive into the questions of how material composition, light intensity, and temperature, among other factors, affect your print and which tools can be used to enable printing of more challenging structures.
Level: Introductory
In this talk, Albane Imbert will provide an overview of the Making Lab Science technology platform work at the Francis Crick Institute, focusing on the development of microphysiological systems and more specifically how to offer reliable tools and methodologies to engineer them. From microfluidics to bioprinting, organoid culture platforms to organ-on-chip, she will discuss opportunities of such tools to be made available on demand in a research institute and the challenges encountered in setting up a new platform for the development of versatile 3D in vitro models.
This is the workshop session to deepen your extrusion based bioprinting skills, learn how to utilise your BIO X and BIO X6 bioprinters full capacity by selecting the right tool head for the right application. The session will focus on how to set up and use the BIO X/X6 bioprinter with the different printheads and how to combine different methods of bioprinting to facilitate a multi-material print.
Level: Introductory
In this talk, Dr. Marco Domingos will provide an overview of Henry Royce Institute’s work in the field of biofabrication for skeletal tissue regeneration. Dr. Domingos will discuss how advanced manufacturing techniques and polymeric inks, mainly those developed in their Lab, can be integrated to support the development of 3D models with tuneable properties and effectively employed in interrogating biological processes associated with tissue morphogenesis. He will highlight some of the major challenges and opportunities in the field of biofabrication and share the vision/mission of the Henry Royce Institute to accelerate the commercial exploitation of bioprinting innovations with potential socio-economic impact in key areas of research including human biology, medicine and drug discovery.
Join us for an inspiring session of Bioprinting Ignited, celebrating achievements and breakthroughs of rising pioneers in the field of bioprinting. This session features the following presentations:
Development and optimisation of highly cellular, embedded bioprinting strategies for the 3D bioprinting of functional cartilage grafts
Kyle Storey, Trinity College
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Exploiting 3D bioprinted models to assess drug response in Chronic Lymphocytic Leukemia
Riccardo Pinos, IRCCS San Raffaele Hospital
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Functional assessment of 3D bioprinted liver tissues from human pluripotent stem cells
Mina Ogawa, McEwen Stem Cell Institute
The agenda is subject to change.
Poster Presentation Hours | 18:00 – 19:30 | Poster titles and authors
Drinks and finger food will be provided.
The agenda is subject to change.
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Dr. Bikramjit Basu is a Professor at the Indian Institute of Science, Bangalore, India. He has been pursuing research at the confluence of Materials Science, Biological Science and Medicine. His research group has effectively applied the principles and tools of these disciplines to develop next generation implants and bioengineering solutions to address unmet clinical needs for musculoskeletal, dental, and neurosurgical applications; thereby impacting human healthcare. A Chartered Engineer of the UK, he has the unique distinction of being the only ceramic scientist from India to get elected to all the major international societies and academies, including the World Academy of Ceramics (2023), the European Ceramic Society (2023), the American Ceramic Society (2019). In India, he is the only engineering scientist to get elected as a Fellow of all the National Academies of Engineering, Science and Medicine, including the Indian National Science Academy (2021), Indian Academy of Sciences (2020), American Ceramic Society (2019), National Academy of Medical Sciences (2017), Indian National Academy of Engineering (2015), Society for Biomaterials & Artificial Organs (2014) and National Academy of Sciences, India (2013). Internationally, he is an elected fellow of the International Union of Societies for Biomaterials Science and Engineering (2020), International Academy of Medical and Biological Engineering (2017) and the American Institute of Medical and Biological Engineering (2015). He is a recipient of India’s most prestigious Science and Technology award, Shanti Swarup Bhatnagar Prize (2013) from the Prime Minister of India; and globally competent awards, like Humboldt Research Award from the Alexander von Humboldt foundation (2022), and International Richard Brook Award from the European Ceramic Society (2022). As the current President (2021-24) of the Society for Biomaterials and Artificial Organs India (1000+ members across India, US and Europe) and the Chair of the Bioceramics Division of the American Ceramic Society, ACerS (2022-23), he has brought transformative changes to significantly enhance international visibility of the biomaterials programs in different countries and to bring together key stakeholders (industry professionals and clinicians), while inspiring several hundreds of young researchers in Bioceramics area across the world.
Tim Woodfield is Professor of Regenerative Medicine, Department of Orthopaedic Surgery & Musculoskeletal Medicine at University of Otago Christchurch and Director of the University of Otago Centre for Bioengineering & Nanomedicine. His research involves development of photo-crosslinkable bioinks and bioresins, 3D Bioprinting, spheroid bioassembly and additive manufacturing of medical devices applied to orthopaedics/regenerative medicine. He has >150 publications (h-index: 51) and obtained >NZ$28M in competitive research funding.
He has received a number of prestigious awards including a Rutherford Discovery Fellowship from the Royal Society of New Zealand Te Apärangi and the University of Otago Research Gold Medal. He received the 2020 Research Excellence Award from the Australasian Society for Biomaterials & Tissue Engineering (ASBTE), and was awarded Fellow Biomaterials Science & Engineering (FBSE).
He is the current President of the International Society for Biofabrication, and former President of the Australasian Society for Biomaterials & Tissue Engineering. He is a member of the Tissue Engineering and Regenerative Medicine International Society Asia Pacific Council (TERMIS-AP) and is an Executive Editorial Board member for Biofabrication journal, as well as Editorial Board Member for Advanced Healthcare Materials, APL Bioengineering and Associate Editor for Frontiers in Bioengineering & Biotechnology.
BIOGRAPHY
Dr. Kaushik Chatterjee joined the Indian Institute of Science, Bangalore, in 2011, where he is currently a Professor in the Department of Materials Engineering and the Department of Bioengineering. His research group focuses on materials for biomedical applications. Specifically, they are using 3D printing and additive manufacturing technologies to prepare medical devices and tissue scaffolds.
Prof. Biman B. Mandal is a Professor in the Department of Biosciences and Bioengineering, School of Health Science and Engineering and Centre for Nanotechnology, IIT Guwahati. Due to his seminal contributions to the field of Biomaterials, Tissue Engineering and 3D Organ Bioprinting, Prof. Mandal is included as one of the “75 under 50 Scientists shaping today’s India” a list prepared by DST, Govt. of India. He is included in “World Top 2% Scientist List” prepared by Stanford University USA. Prof. Mandal is an Associate Editor of ACS Biomaterials Science and Engineering and Editorial Board member of 10 International high impact Journals. He was the President of STERMI (Society for Tissue Engineering and Regenerative Medicine India) 2021-2024.
Prof. Mandal has published more than 190 research articles with over 11,600+ citations and has an H-index of 60. He has 23 patents and licensed 05 healthcare technologies to Industry with 01 product already in market. Prof. Mandal has bagged prestigious Young scientist awards from the Indian National Academy of Sciences (INSA) and National Academy of Sciences India (NASI). He has won NASI-SCOPUS Young Scientist award for his high citations and B. M. BIRLA Science Prize in Biology along with 06 other prestigious young scientist awards. Recently he has been awarded the prestigious SWARNAJAYANTI Fellowship & S. RAMACHANDRAN National Bioscience Award by DST and DBT in Life Sciences for the year 2020-2021.
Neetu Singh obtained her Bachelors and Masters degrees from University of Mumbai and her doctoral degree in chemistry from Georgia Institute of Technology, Atlanta, USA. She obtained her postdoctoral training at the Harvard-MIT Division of Health Sciences and Technology, USA.
Prof. Singh returned to India and joined IIT Delhi as an Assistant Professor in the Center for Biomedical Engineering in 2014.
In her current program at IITD, she is establishing a research program that explores systematic probing into nanomaterials biological activity and formulates “design rules” for developing nanosystem for specific bio-medical & healthcare applications. Her group at IIT Delhi is integrating concepts and skills from chemistry, materials science, and biology to design nano-structured materials with enhanced functionalities for applications in biomedical implants, disease diagnostics, tissue engineering and regenerative medicine.
Her scientific contribution has been recognized by several awards and honors. She is the recipient of “Innovative Young Biotechnologist award 2013” by Department of Biotechnology (DBT), India. In 2019, she received the Veena Arora young researcher award by IIT Delhi, which recognizes best research contributions at IIT Delhi by faculty below 40 years. She is the receipt of NASI-SCOPUS young Scientist award for “Women-in Science”-2019; DBT’s Janaki Ammal Young scientist -2021 and Science and Engineering Research Board (SERB)-India, POWER Fellow 2021. She is also a mentor for an IITD start-up, “Kriya-Labs”, that is bringing valorization to agro waste by technological solutions.
She is also an editorial advisory board member of the journal Bioconjugate Chemistry (a pioneering publication of American Chemical Society) and a new Springer journal – In Vitro Models.
Dr. Baiju G Nair is an Associate Professor and Head of the Department of Bioscience and Engineering at NIT Calicut, where he leads the Functional Materials and Tissue Engineering Laboratory. His academic journey began with an MS and Doctor of Engineering in Bionanofusion Technology as a MEXT fellow in Japan, showcasing his dedication to pioneering research.
After completing his doctoral degree, Dr. Nair was honored with the prestigious JSPS fellowship at Riken, Japan, in 2012, followed by recognition through the SPDR program for young scientists in 2014. His commitment to excellence was further acknowledged in 2023 with the Bridge Fellowship by JSPS.
Dr. Nair is renowned for his prolific research contributions, evident through numerous peer-reviewed articles, books, and secured patents in his specialized domains. His outstanding achievements include receiving the Young Scientist Award from the Biomedical Engineering Forum in Japan in 2017 and the Best Research Award at Nanocon in the Czech Republic in 2011.
His research interests encompass a broad spectrum, ranging from tissue engineering and 3D & 4D bioprinting to biomaterials, DNA and RNA nanotechnology, and exploring small molecules from extremophiles. Dr. Nair’s innovative work enriches the scientific community and promises groundbreaking advancements in healthcare and biotechnology.
Dr. Falguni Pati, currently an Associate Professor and the Head of the Department of Biomedical Engineering at IIT Hyderabad, boasts an impressive academic and research background. He obtained his Ph.D. from IIT Kharagpur and gained valuable experience through postdoctoral appointments at POSTECH, South Korea, and KTH, Sweden, before joining IITH in 2015. Dr. Pati leads the Biofabrication and Tissue Engineering (BioFabTE) Lab at IITH, where the primary focus lies in advancing tissue engineering through 3D bioprinting technology. His lab endeavors to develop innovative tissue-engineered products and in vitro tissue/organ models, with a keen interest in bioinks, bioprinting methods, and technologies to produce tissue analogs-on-demand. Dr. Pati’s contributions extend beyond research into academia. He designed and implemented a pioneering course on Biofabrication for undergraduate and postgraduate students at IITH, the first of its kind in India. Additionally, he has been teaching the course “Organ Printing” on NPTEL for the last three years, further disseminating knowledge in this specialized domain.
Recognition for his impactful work includes the prestigious Ramalingaswami fellowship awarded to him in 2016. Dr. Pati’s research endeavors have been supported by various funding agencies such as DST-SERB, DBT, ICMR, and MoE, underscoring the significance and relevance of his research initiatives.
Notably, in 2022, Dr. Pati’s team achieved a significant milestone by securing the Sree Ramakrishna Paramahamsa Research Grant worth 3 Cr in Biomedical Sciences. This grant was awarded for the clinical trial of their biomimetic hydrogel, showcasing the potential impact of their research in addressing blinding corneal diseases.
BIOGRAPHY
Prof Lamprou (Ph.D., MBA) is the Chair of Biofabrication and Advanced Manufacturing at Queen’s University Belfast, the Chair at UKICRS and the Chair of the APS Emerging Technologies Focus Group. Is the author of 150+ peer-reviewed publications, has 350+ conference abstracts, has given 150+ Invited Talks across the world, and has secure Funding more than £3M. Has been recognized as world leader in 3D Printing with PubMed-based algorithms placed him in the top 0.088% of scholars in the world. Has also been named in the Stanford University’s list 2021 & 2022 of World’s Top 2% Scientists. For more info, click here.
BIOGRAPHY
CTO and Board member at Ossiform.
Has several years of experience in the development of additive manufacturing processes of medical devices and patient specific implants.
Lead responsible for Ossiform’s Production, R&D and IP.
Core achievements include the setup of Ossiform’s production conforming to ISO 13485 guidelines, with a production of +1000 implants for premarket testing, validation of the Ossiform material for intended human use, development and subsequent granting of Ossiform’s IP worldwide, as well as the adaptation of the company’s material for Point of Care Printing.
Key contributor in Ossiform’s cumulated capital raise of +$10M.
Has a M.Sc. degree in Engineering of Health Technology.
BIOGRAPHY
Peyman Kelk is a university lecturer in anatomy at the Department of Integrative Medical Biology, Umeå University, Sweden. He obtained his dental degree in 2002 and completed his doctoral studies in the field of periodontology in 2009. In 2013, he became a specialist in prosthodontics and currently holds a combined position where he combines clinical work in prosthodontics with lecturing position in anatomy. His research initially focused on host-parasite interactions, but after his dissertation, he shifted his research towards stem cell biology and regenerative medicine, including 3D bioprinting for hard tissue applications. Today, he works in a larger group of researchers with the aim of making regenerative medicine and stem cell biology clinically applicable.
BIOGRAPHY
Prof. Levenberg is the former Dean of the Biomedical Engineering Department at the Technion. She currently serves as the director of the Technion Center for 3D Bioprinting and The Rina & Avner Schneur Center for Diabetes Research. Prof Levenberg has received numerous prizes including the Krill Prize for excellence in scientific research, awarded by the Wolf Foundation, and was named by Scientific American as a “Research Leader” in tissue engineering, for her seminal work on vascularization of engineered tissues. She has also received the Rappaport Prize for Excellence in Biomedical Sciences and a Medal of Distinction from the Peres Center for Peace and Innovation. Prof Levenberg has authored over 150 publications, and presented her work as an invited lecturer in over 150 international conferences including as a keynote or plenary lecturer. She is founder and CSO of three start-up companies in the areas of cultured meat, spinal cord regeneration and nanoliter arrays for rapid antimicrobial susceptibility testing.
Prof Levenberg earned a PhD at the Weizmann Institute of Science, where she focused on cell adhesion dynamics and signaling, and pursued her post-doctoral research in tissue engineering at MIT, in the lab of Professor Robert Langer. Prof Levenberg spent a year as a visiting professor at the Wyss Institute for Biology Inspired Engineering at Harvard University.
BIOGRAPHY
Kieran Casey serves as Carcinotech’s Head of Business Development bringing a background in cell & molecular biology and over 20 years commercial experience supporting drug discovery and life science researchers. Originally as a postgraduate and researcher at UCL’s Biochemical Engineering Faculty via technical support roles at Thermo, Beckman Coulter and Perkin Elmer through to sales leadership roles within Veolia, Affymetrix and BioIVT.
Over the last 10 years he has been involved in Business Development with several preclinical and clinical CRO companies offering innovative solutions such as HCS, pharmacogenomic screening, iPSCs, gene editing services etc to the global drug discovery market.
As Head of Business Development at Carcinotech he oversees the creation and execution of the company’s global business development strategy and delivery of Carcinotech’s innovative platform and solutions to the drug discovery and diagnostic community.
BIOGRAPHY
Albane is head of the Making Lab, a Science Technology Platform at the Crick, that focuses on combining approaches from engineering and biomedical research to develop innovative systems to investigate biomedical research questions from neuroscience to cell development, stem cell or cancer biology. She is particularly interested in biomaterial and biomanufacturing processes to develop new in vitro platforms with direct applications to fundamental research conducted at the Crick and the wider research community.
BIOGRAPHY
Dr. Marco Domingos is a Senior Lecturer/Associate Professor in the Department of Mechanical, Aerospace, and Civil Engineering at the University of Manchester (UK). He graduated in Mechanical Engineering (2006) from the Polytechnic Institute of Leiria (Portugal) and holds a Ph.D. (2013) cum laude in Mechanical Engineering from the University of Girona (Spain). He was elected fellow of the Higher Education Academy (UK) in 2016 and fellow of the Institution of Mechanical Engineers (FIMechE, UK) in 2017. He holds several visiting positions at prestigious institutions including visiting Professor at the Centre for Rapid and Sustainable Product Development (CDRSP, Portugal) and at The University of Naples, Federico II (Naples, Italy). Since 2021 he is the Technology Platform Lead for Bioprinting at the Henry Royce (https://www.royce.ac.uk/technology-platforms/bioprinting-platform/), the UK national institute for advanced materials and innovation, where his group is focusing on the development of advanced biomaterials and biofabrication technologies for application in regenerative medicine. He has authored or co-authored more than 50 scientific publications, including articles in peer-reviewed international journals, books and book chapters obtaining over 3436 citations (H index: 26).