Biomaterials science and biomedical engineering have sustained as one among frontier and growing areas of research and innovation within the engineering science community in the world; considering the number of scientific discoveries and their societal impact. Significant attempts were largely directed to re-create functional musculoskeletal systems with considerable potential to treat various types of human diseases. At the beginning of my presentation, I will present multiscale measurements and analysis to quantitatively understand the process physics of binderjet 3D printing. I will present some of our recent results to demonstrate the efficacy of the 3D powder printing to fabricate Sr-substituted Mg-phosphate bioceramic scaffolds and Zirconia bioceramics, albeit with specific challenges. A major emphasis will be placed on the binder formulation, post-processing treatment, and micro-computed tomography of interconnected porous architecture together with the strength reliability. One of the most recent clinical translational attempts to treat decompressive craniectomy using 3D powder printed patient-specific cranial prosthesis will be presented. Towards the end, the recent results of 3D bioprinting will be presented. It will be shown as how the hydrothermally synthesized nanocrystalline needle-shaped HAp particles (<30 nm) were incorporated into pre-crosslinked gelatin methacryloyl (GelMA) hydrogel to obtain a better combination of compression strength (~ 300 kPa) and elastic modulus (~ 300 kPa) in a designed scaffold. We propose that the inorganic-organic nanocomposite hydrogel could be efficiently assembled to formulate a potential bioink for 3D bioprinting applications towards bone tissue regeneration. This lecture will close by introducing a new concept, Biomaterialomics, which brings together Biomaterials science and Data Science.
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In the realm of tissue engineering, 3D bioprinting stands out as a revolutionary technology with immense potential. By allowing precise printing and patterning of cells and matrix materials in three dimensions, 3D bioprinting enables the recreation of tissue structures that closely mimic their natural counterparts. This capability holds the promise of generating tissue-mimetic constructs capable of replicating the functions of specific tissues within the body.
At our lab, we’ve been exploring a biomimetic approach to 3D bioprinting, which involves mimicking the intricate structure and organization of native tissues. One key aspect of our approach is the utilization of decellularized tissue matrix bioink, which provides a natural scaffold rich in extracellular matrix components necessary for cell adhesion, proliferation, and differentiation.
During my talk, I will delve into the various modalities of bioprinting, each with its unique mechanisms and operations. By discussing the differences between these modalities, attendees will gain a comprehensive understanding of the bioprinting landscape and the specific advantages each technique offers.
Furthermore, I’ll share insights into our ongoing research projects at the lab, particularly focusing on our use of extrusion-based 3D bioprinting. This method allows for precise deposition of bioink materials, enabling the creation of complex tissue constructs with tailored properties.
Moreover, I’ll highlight some of our translational works that are progressing toward clinical trials. These projects represent the culmination of our efforts to bridge the gap between cutting-edge research and real-world applications, with the ultimate goal of developing novel tissue-engineered therapies to address clinical needs.
Join us for an exciting session of Bioprinting Ignited, where two speakers will be selected from the Abstract Submissions, to inspire us with their research. Submit your abstract here to be considered.
The agenda is subject to change.
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Dr. Bikramjit Basu is a Professor at the Indian Institute of Science, Bangalore, India. He has been pursuing research at the confluence of Materials Science, Biological Science and Medicine. His research group has effectively applied the principles and tools of these disciplines to develop next generation implants and bioengineering solutions to address unmet clinical needs for musculoskeletal, dental, and neurosurgical applications; thereby impacting human healthcare. A Chartered Engineer of the UK, he has the unique distinction of being the only ceramic scientist from India to get elected to all the major international societies and academies, including the World Academy of Ceramics (2023), the European Ceramic Society (2023), the American Ceramic Society (2019). In India, he is the only engineering scientist to get elected as a Fellow of all the National Academies of Engineering, Science and Medicine, including the Indian National Science Academy (2021), Indian Academy of Sciences (2020), American Ceramic Society (2019), National Academy of Medical Sciences (2017), Indian National Academy of Engineering (2015), Society for Biomaterials & Artificial Organs (2014) and National Academy of Sciences, India (2013). Internationally, he is an elected fellow of the International Union of Societies for Biomaterials Science and Engineering (2020), International Academy of Medical and Biological Engineering (2017) and the American Institute of Medical and Biological Engineering (2015). He is a recipient of India’s most prestigious Science and Technology award, Shanti Swarup Bhatnagar Prize (2013) from the Prime Minister of India; and globally competent awards, like Humboldt Research Award from the Alexander von Humboldt foundation (2022), and International Richard Brook Award from the European Ceramic Society (2022). As the current President (2021-24) of the Society for Biomaterials and Artificial Organs India (1000+ members across India, US and Europe) and the Chair of the Bioceramics Division of the American Ceramic Society, ACerS (2022-23), he has brought transformative changes to significantly enhance international visibility of the biomaterials programs in different countries and to bring together key stakeholders (industry professionals and clinicians), while inspiring several hundreds of young researchers in Bioceramics area across the world.
Tim Woodfield is Professor of Regenerative Medicine, Department of Orthopaedic Surgery & Musculoskeletal Medicine at University of Otago Christchurch and Director of the University of Otago Centre for Bioengineering & Nanomedicine. His research involves development of photo-crosslinkable bioinks and bioresins, 3D Bioprinting, spheroid bioassembly and additive manufacturing of medical devices applied to orthopaedics/regenerative medicine. He has >150 publications (h-index: 51) and obtained >NZ$28M in competitive research funding.
He has received a number of prestigious awards including a Rutherford Discovery Fellowship from the Royal Society of New Zealand Te Apärangi and the University of Otago Research Gold Medal. He received the 2020 Research Excellence Award from the Australasian Society for Biomaterials & Tissue Engineering (ASBTE), and was awarded Fellow Biomaterials Science & Engineering (FBSE).
He is the current President of the International Society for Biofabrication, and former President of the Australasian Society for Biomaterials & Tissue Engineering. He is a member of the Tissue Engineering and Regenerative Medicine International Society Asia Pacific Council (TERMIS-AP) and is an Executive Editorial Board member for Biofabrication journal, as well as Editorial Board Member for Advanced Healthcare Materials, APL Bioengineering and Associate Editor for Frontiers in Bioengineering & Biotechnology.
BIOGRAPHY
Dr. Kaushik Chatterjee joined the Indian Institute of Science, Bangalore, in 2011, where he is currently a Professor in the Department of Materials Engineering and the Department of Bioengineering. His research group focuses on materials for biomedical applications. Specifically, they are using 3D printing and additive manufacturing technologies to prepare medical devices and tissue scaffolds.
Prof. Biman B. Mandal is a Professor in the Department of Biosciences and Bioengineering, School of Health Science and Engineering and Centre for Nanotechnology, IIT Guwahati. Due to his seminal contributions to the field of Biomaterials, Tissue Engineering and 3D Organ Bioprinting, Prof. Mandal is included as one of the “75 under 50 Scientists shaping today’s India” a list prepared by DST, Govt. of India. He is included in “World Top 2% Scientist List” prepared by Stanford University USA. Prof. Mandal is an Associate Editor of ACS Biomaterials Science and Engineering and Editorial Board member of 10 International high impact Journals. He was the President of STERMI (Society for Tissue Engineering and Regenerative Medicine India) 2021-2024.
Prof. Mandal has published more than 190 research articles with over 11,600+ citations and has an H-index of 60. He has 23 patents and licensed 05 healthcare technologies to Industry with 01 product already in market. Prof. Mandal has bagged prestigious Young scientist awards from the Indian National Academy of Sciences (INSA) and National Academy of Sciences India (NASI). He has won NASI-SCOPUS Young Scientist award for his high citations and B. M. BIRLA Science Prize in Biology along with 06 other prestigious young scientist awards. Recently he has been awarded the prestigious SWARNAJAYANTI Fellowship & S. RAMACHANDRAN National Bioscience Award by DST and DBT in Life Sciences for the year 2020-2021.
Neetu Singh obtained her Bachelors and Masters degrees from University of Mumbai and her doctoral degree in chemistry from Georgia Institute of Technology, Atlanta, USA. She obtained her postdoctoral training at the Harvard-MIT Division of Health Sciences and Technology, USA.
Prof. Singh returned to India and joined IIT Delhi as an Assistant Professor in the Center for Biomedical Engineering in 2014.
In her current program at IITD, she is establishing a research program that explores systematic probing into nanomaterials biological activity and formulates “design rules” for developing nanosystem for specific bio-medical & healthcare applications. Her group at IIT Delhi is integrating concepts and skills from chemistry, materials science, and biology to design nano-structured materials with enhanced functionalities for applications in biomedical implants, disease diagnostics, tissue engineering and regenerative medicine.
Her scientific contribution has been recognized by several awards and honors. She is the recipient of “Innovative Young Biotechnologist award 2013” by Department of Biotechnology (DBT), India. In 2019, she received the Veena Arora young researcher award by IIT Delhi, which recognizes best research contributions at IIT Delhi by faculty below 40 years. She is the receipt of NASI-SCOPUS young Scientist award for “Women-in Science”-2019; DBT’s Janaki Ammal Young scientist -2021 and Science and Engineering Research Board (SERB)-India, POWER Fellow 2021. She is also a mentor for an IITD start-up, “Kriya-Labs”, that is bringing valorization to agro waste by technological solutions.
She is also an editorial advisory board member of the journal Bioconjugate Chemistry (a pioneering publication of American Chemical Society) and a new Springer journal – In Vitro Models.
Dr. Baiju G Nair is an Associate Professor and Head of the Department of Bioscience and Engineering at NIT Calicut, where he leads the Functional Materials and Tissue Engineering Laboratory. His academic journey began with an MS and Doctor of Engineering in Bionanofusion Technology as a MEXT fellow in Japan, showcasing his dedication to pioneering research.
After completing his doctoral degree, Dr. Nair was honored with the prestigious JSPS fellowship at Riken, Japan, in 2012, followed by recognition through the SPDR program for young scientists in 2014. His commitment to excellence was further acknowledged in 2023 with the Bridge Fellowship by JSPS.
Dr. Nair is renowned for his prolific research contributions, evident through numerous peer-reviewed articles, books, and secured patents in his specialized domains. His outstanding achievements include receiving the Young Scientist Award from the Biomedical Engineering Forum in Japan in 2017 and the Best Research Award at Nanocon in the Czech Republic in 2011.
His research interests encompass a broad spectrum, ranging from tissue engineering and 3D & 4D bioprinting to biomaterials, DNA and RNA nanotechnology, and exploring small molecules from extremophiles. Dr. Nair’s innovative work enriches the scientific community and promises groundbreaking advancements in healthcare and biotechnology.
Dr. Falguni Pati, currently an Associate Professor and the Head of the Department of Biomedical Engineering at IIT Hyderabad, boasts an impressive academic and research background. He obtained his Ph.D. from IIT Kharagpur and gained valuable experience through postdoctoral appointments at POSTECH, South Korea, and KTH, Sweden, before joining IITH in 2015. Dr. Pati leads the Biofabrication and Tissue Engineering (BioFabTE) Lab at IITH, where the primary focus lies in advancing tissue engineering through 3D bioprinting technology. His lab endeavors to develop innovative tissue-engineered products and in vitro tissue/organ models, with a keen interest in bioinks, bioprinting methods, and technologies to produce tissue analogs-on-demand. Dr. Pati’s contributions extend beyond research into academia. He designed and implemented a pioneering course on Biofabrication for undergraduate and postgraduate students at IITH, the first of its kind in India. Additionally, he has been teaching the course “Organ Printing” on NPTEL for the last three years, further disseminating knowledge in this specialized domain.
Recognition for his impactful work includes the prestigious Ramalingaswami fellowship awarded to him in 2016. Dr. Pati’s research endeavors have been supported by various funding agencies such as DST-SERB, DBT, ICMR, and MoE, underscoring the significance and relevance of his research initiatives.
Notably, in 2022, Dr. Pati’s team achieved a significant milestone by securing the Sree Ramakrishna Paramahamsa Research Grant worth 3 Cr in Biomedical Sciences. This grant was awarded for the clinical trial of their biomimetic hydrogel, showcasing the potential impact of their research in addressing blinding corneal diseases.