Single-Cell Encapsulation for Improved Cell Therapies

Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system. Efforts to address these issues by suspending MSCs in protective biomaterials have resulted in bulky hydrogels that are too large to be given intravenously and can stifle the MSCs’ function.

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