Karolinska Institute and Science for Life Laboratory have developed a new method called CUTseq, a cost-effective way to identify highly heterogenous tumors that are often very aggressive and require aggressive treatments. The method works with DNA extracted from multiple biopsies and even from very small portions of thin tissue sections, i.e., the type of sample that pathologists commonly rely on to make a diagnosis of cancer under the microscope. The research has been recently published in the scientific journal Nature Communications.
Outside of cancer research, CUTseq is also used as a method of authenticating cell lines and monitoring throughput. Traditionally, liquid handling is sensitive to cross contamination. This study showed I-DOT was not susceptible to cross contamination during the CUTseq workflow, which corresponds to reduced costs, faster results and enhanced reproducibility. Using the I-DOT, the researchers were able to complete the entire workflow from taking the extracted RNA and DNA all the way through library purification to results in ~8 hours.
I-DOT is developed by Germany-based company Dispendix GmbH, a company CELLINK acquired in November 2018 to increase its presence in the pharmaceutical industry market. The results of this study lay the groundwork for I-DOT’s use in oncological research and can support additional applications in cell line development.
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CELLINK is the leading 3D bioprinter provider and the first bioink company in the world. We focus on developing and commercializing bioprinting technologies to allow researchers to print human organs and tissues for pharmaceutical and cosmetic applications. Founded in 2016 and active in more than 50 countries, CELLINK is changing the future of medicine as we know it. Visit www.cellink.com to learn more. CELLINK is listed on Nasdaq First North Growth Market under CLNK. Erik Penser Bank AB is the company’s certified adviser, available by phone at +46 846 383 00 and by email at: [email protected].