The INKREDIBLE+ Bridges the 3D Materials Gap: From Nano- to Macroscale

Institution
Massachusetts Institute of Technology
Research team
Hui Sun and Benedetto Marelli
Challenge
The assembly of biomacromolecules into nanostructures has advanced recently, however, transitioning the molecular disorder to macroscale structures has remained challenging.
Solution
Researchers at MIT used templated silk fibroin crystallization along with the INKREDIBLE to assemble ordered peptide supramolecular 3D patterns. The INKREDIBLE enabled the continuous printing of silk gels in order to facilitate the orientational arrangement of silk nanofibrils induced by the printing shear force.
Results
The results of the study suggest that the template-based bottom-up approach guides hierarchical material growth from disordered molecules up to the macroscale. The templated crystallization method along with 3D printing may allow for the generation of new macroscopic nanostructured materials with applications ranging from regenerative medicine to information storage and encryption.
Read more
Sun, H., Marelli, B. Polypeptide templating for designer hierarchical materials. Nat Commun 11, 351 (2020). https://doi.org/10.1038/s41467-019-14257-0