CELLINK LAMININKs

Re-create the natural tissue environment.

Laminins are proteins composed of three subunits (α-chain, β-chain and γ-chain) and are major components of the basal lamina that lines the external surface of cell membranes. These proteins, characterized by their cross-like forms, serve as structural foundations for many tissue types. Laminins play an important role in cell differentiation, migration, adhesion, improving the maintenance and survival of living tissues.

CELLINK LAMININKs include five tissue-specific bioinks, which include the laminin types related to specific tissues and organs in the human body. All these bioinks retain the excellent printability and ease of crosslinking that distinguish the universal CELLINK Bioink.

CELLINK Laminink series

LAMININK 521

Supports different tissues types, including pluripotent and embryonic stem cells and induces their self-renewal. Supports many cell types, including cells from pancreas, vascular, nervous and muscular systems.

LAMININK 121

Used as the starting point for culture of multiple cell types. Eexpressed widely during embryonic and early development stages of organ and tissue lining. Mostly found in placenta, skeletal muscle and kidney tissue.

LAMININK 411

Supports different tissues types, including tissues from the pancreas, vascular, immune, nervous and hematopoietic systems. A suitable base material for culturing specific cell types, including pancreatic cells and neurons.

LAMININK +

The CELLINK LAMININK + contains several laminins and offers excellent printability and easy crosslinking. The bioink is also a great starting point for culturing many cell types in 3D.

LAMININK 111

An important protein during early development when lining tissues and organs. This bioink is relevant for studying Parkinson’s disease and cancer models. Great starting point for culturing many cell types in 3D.

CELLINK LAMININKS IN ACTION

When GFP-labeled iPSC-derived motor neurons were 3D bioprinted in a custom-made CELLINK LAMININK blend, the neurons developed a 3D neural network between clusters and formed internal networks between cells. This image shows clusters of motor neurons at Day 17 of culturing in the CELLINK LAMININK blend.

Another example comes from the work of our customer Associate Professor Cristina Scielzo at San Raffaele Scientific Institute in Italy, who 3D bioprinted primary leukemic cells in CELLINK LAMININK 111 and investigated their cross-talk with the microenvironment after 14 days of culture. Confocal microscopy of 3D bioprinted leukemic cells in CELLINK LAMININK 111 after 14 days of culturing (red = phalloidin staining, and blue = DAPI).