3D-bioprinted disease models to accelerate therapeutic discoveries in vitro.
While animal models and 2D cell cultures have advanced our understanding of the molecular mechanisms associated with diseases and their progression, drug development efforts most often fail in clinical testing because of poor efficacy in humans.
Recently, there has been tremendous interest and success in modeling human diseases through 3D cell cultures which can better recapitulate human organ microenvironments. In vitro testing of therapeutics in human organ models offers researchers a new toolbox with the potential to significantly accelerate discovery and prevent late-stage clinical failures.
A new toolbox
With advances in bioprinter technologies and bioinks that mimic native organ microenvironments, we can now strategically fabricate more physiologically relevant models that include specific cell types, ideal mechanical properties and more appropriate spatial patterning of the cells. Such dynamic models can be fabricated with diseased cells, such as tumor cells, patient-derived cells or with healthy cell lines that can be further stimulated to promote disease progression.
Generating disease models
Our bioprinters, such as the BIO X and LUMEN X, allow for the automated fabrication of complex tissue architectures that can be tailored for specific organ types. The BIO X bioprinters have three and six print heads, which can be loaded with different cell types and bioinks. A variety of bioinks have been developed for tissue-specific applications and can be used to mimic natural tissue patterns. The extrusion-based BIO X systems can 3D-print more physiologically relevant disease models or healthy tissue models in a high-throughput manner into 96- or 384 well plates, or in single bulk tissues with larger cell culture dishes. Light-based bioprinting with the LUMEN X and HOLOGRAPH X allows for the generation of vascularized tissues.
Disease Induction and compound screening
In addition to bioprinters and bioinks, we provide user-friendly low volume dispensing instruments. Using the I-DOT, healthy tissues that were fabricated with bioprinters can be stimulated with bioactive agents in a precise and automated manner. The I-DOT makes it possible to accurately dose bioactive agents for disease induction, to rapidly generate dilution series or to screen the response in the presence of thousands of compounds or combinations thereof.
Tumor Spheroid Formation Using the I-DOT
Compared to standard liquid handlers, the I-DOT can perform combinatorial dispensing patterns efficiently. The I-DOT One offers a simple, reliable and robust non-contact pressure-based dispensing.
The most user-friendly bioprinter in the world thanks to its open system, intelligent and interchangeable printheads. Assists in developing complex tissue constructs, testing new drug compounds and streamline workflows in a range of application areas
The most flexible six-printhead bioprinting platform on the market and the preferred system for those ready to make history. With the BIO X6 in your lab, you can combine more materials, cells and tools — and get your results sooner — than ever before
Enhancing applications such as microfluidics, cell-laden hydrogels and macroporous structures. Designed to print vasculature with biocompatible blue light, it offers advantages in achieving complex branching and tapering of vessels.
We developed the world’s first universal bioink. Today, hundreds of labs use it in more than 50 countries worldwide. We continue to design innovative bioinks with excellent printability and bioactive properties that guide cellular fate processes.
The CELLCYTE X is the premier solution to maximize insights from your cell culture experiments. Designed to fit in most incubators, users can harness the power of live cell imaging and uncover answers to today’s most pressing questions.
Laser-based bioprinter able to recreate human physiology at sub-micrometer resolutions within minutes. Fully automated, it accepts any user-designed structure and laser prints transplantable 3D tissue scaffolds for research and therapeutic development.