Application Notes

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Clonal cell line development is a crucial step for biopharmaceutical generation (e.g., the production of monoclonal antibodies). To ensure a consistent product, the cell lines used in production must originate from a single cell.

Combined Single-cell Dispensing and 3D Full Well Imaging for Cell Lines with >99.99% Probability of Monoclonality (English)

Clonal cell line development is a crucial step for biopharmaceutical generation (e.g., the production of monoclonal antibodies). To ensure a consistent product, the cell lines used in production must originate from a single cell.
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We demonstrate an efficient, high-throughput workflow that incorporates the f.sight™ for both selection and cloning of CRISPR/Cas9-edited mesenchymal stem cells (MSCs). Here, MSCs underwent gene editing to knockout the RANKL protein to further enhance the therapeutic capacity of MSCs in regenerative medicine.

Streamlined Workflow for the Generation of CRISPR-edited Mesenchymal Stem Cell Clones for Regenerative Medicine Applications

We demonstrate an efficient, high-throughput workflow that incorporates the f.sight™ for both selection and cloning of CRISPR/Cas9-edited mesenchymal stem cells (MSCs). Here, MSCs underwent gene editing to knockout the RANKL protein to further enhance the therapeutic capacity of MSCs in regenerative medicine.
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Our study demonstrates that the c.bird™ improves mammalian cell growth in 96-well culture environments and closely imitates the shaker-flask culture in terms of cell growth profiles and protein yields.

Providing Optimal Suspension Culture Conditions in 96-well Plates and Superior Comparability with Large-scale Shaker-flask Culture Environments

Our study demonstrates that the c.bird™ improves mammalian cell growth in 96-well culture environments and closely imitates the shaker-flask culture in terms of cell growth profiles and protein yields.
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