The I-DOT Automates the Nanoscale Synthesis of More Than 1000 Iminopyrrolidine Derivatives

Institution

University of Groningen

Research team

Angelina Osipyan, Shabnam Shaabani, Robert Warmerdam, et al.

Challenge

Drug development and chemical synthesis research is often expensive, slow, and can have ecological impacts from the associated high usage of solvents and reagents. Cost effective and timely approaches for the discovery of novel drugs and materials is greatly needed. With rapidly advancing tools in big data and artificial intelligence; the combination with automation and miniaturization of synthetic chemistry holds tremendous potential in accelerating therapeutic discoveries.

Solution

The team at University of Groningen used the I-DOT, a low‐volume non‐contact dispenser, to automate the nanoscale synthesis of more than 1000 different derivatives of iminopyrrolidines. The work was part of their ongoing efforts to create libraries of proteolysis targeting chimeras (PROTAC), an emerging and promising cancer therapeutics approach.

Results

The results of the study suggest that the I-DOT rapid nanoliter dispensing technology considerably reduces errors, increases speed and safety, and is more economically and ecologically viable than traditional chemical synthesis methods.

Read more

https://onlinelibrary.wiley.com/doi/10.1002/anie.202000887

Relevant products for this post

More Customer Spotlights

Researchers at Rensselaer Polytechnic Institute have developed a way to 3D print living skin, complete with blood vessels. The advancement, published online today in Tissue Engineering Part A, is a significant step toward creating grafts that are more like the skin our bodies produce naturally
Using human blood cells, Brazilian researchers have obtained hepatic organoids ("mini-livers") that perform all of the liver's typical functions, such as producing vital proteins, storing vitamins and secreting bile, among many others.
With the help of a BIO X printer, scientists in the Department of Applied Science and Technology validated the use of bioprinted collagen nanocomposites for high-resolution scaffolds, taking a significant step toward producing more biomimetic patient-specific bone-like scaffolds on demand. With millions affected by osteoporosis and degradation of bone mechanics such regenerative medicine strategies are urgently needed.
Bioengineers from Tufts University coupled the INKREDIBLE with a novel printing technique to achieve hierarchical assembly of silk fibroin molecules into 3D macroscale architectures that have intrinsic biocompatibility, as well as exceptional mechanical strength and shape complexity.