The I-DOT Automates the Nanoscale Synthesis of More Than 1000 Iminopyrrolidine Derivatives


University of Groningen

Research team

Angelina Osipyan, Shabnam Shaabani, Robert Warmerdam, et al.


Drug development and chemical synthesis research is often expensive, slow, and can have ecological impacts from the associated high usage of solvents and reagents. Cost effective and timely approaches for the discovery of novel drugs and materials is greatly needed. With rapidly advancing tools in big data and artificial intelligence; the combination with automation and miniaturization of synthetic chemistry holds tremendous potential in accelerating therapeutic discoveries.


The team at University of Groningen used the I-DOT, a low‐volume non‐contact dispenser, to automate the nanoscale synthesis of more than 1000 different derivatives of iminopyrrolidines. The work was part of their ongoing efforts to create libraries of proteolysis targeting chimeras (PROTAC), an emerging and promising cancer therapeutics approach.


The results of the study suggest that the I-DOT rapid nanoliter dispensing technology considerably reduces errors, increases speed and safety, and is more economically and ecologically viable than traditional chemical synthesis methods.

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