CELLINK

Materials for bioink development

Get started with your own bioink formulations.

Formulating your own bioink does not have to be difficult.

With an extensive portfolio of all the must-haves for developing reliably reproducible custom bioink formulations in no time. Our base materials, thickeners and crosslinkers are standardized and quality controlled to ensure they will yield consistent and reproducible results. Developing and customizing bioink formulations that can be reliably reproduced starts with these high-quality components.

Concentrated components

Fine-tune formulations by reconstituting components.

Want complete control over your bioink development? Does your bioink manufacturing require a specific concentration? Many of our biomaterials and bioink components are available as sterile lyophilizates and powders that can be reconstituted to any concentration in order to fine-tune properties. These biomaterials are also packaged in kits that include reconstitution agents, crosslinkers and consumables to get you started even faster.

Explore our range of Concentrated Components

GelMA Lyophilizate

Freeze-dried product of porcine gelatin functionalized with methacrylate groups. It is one of the most popular biomaterials in tissue engineering, used in a variety of applications.

HAMA Lyophilizate

Sterile powder version of methacrylated hyaluronic acid. Add sterile buffer to reconstitute at your desired concentration and you can start incorporating your bioinks and other 3D cell culture constructs.

Alginate Lyophilizate

Naturally derived polysaccharide isolated from the cell walls of brown algae.

Coll 1 Lyophilizate

One of the main structural proteins found in extracellular matrix (ECM) and connective tissue. Found in over 30% of total body protein, making it an excellent biomaterial for tissue engineering and 3D printing applications

Pluronics powder

Can be dissolved in water to create hydrogels with excellent printability.

ColMA Lyophilizate

A unique variation of rat tail derived collagen type I that has been modified with photoactive methacrylate groups, enabling it to be crosslinked in the presence of a photoinitiator.

Stock Solutions

Quickly iterate in your bioink development.

Many of our biomaterials and bioink components are available in sterile, high concentrations that can be quickly mixed and diluted to develop custom bioinks. Additionally, be sure you check out our library of thickeners to impart shear-thinning characteristics and enhance printability.

Explore our range of Stock Solutions

GelMA 20 %

A concentrated solution at physiological pH and osmolarity, to be used as a base in bioink formulation

HAMA 5 %

This concentrated solution of 5% HAMA is easy to dilute with our Reconstitution Agent P or used as a supplement in your own bioink formulation.

Pluronics 40 %

A ready-to-print sacrificial and support ink that exhibits excellent printability. Optimized for the fabrication of vascularized tissues, channels in microfluidic devices, and supporting scaffolds for complicated tissue constructs.

Alginate 5 %

Viscous alginate hydrogel, suitable for both bioprinting and casting. Use it on its own, mix it with another hydrogel to make the blend ionically crosslinkable or dilute it using our Reconstitution Agent M to achieve your target concentration.

Thickeners

Stabilize bioinks to facilitate printability.

Thickening agents serve a critical role in the development of a bioink by imparting shear-thinning characteristics that facilitate stabilization and printability. Many of our thickening agents are available for bioink development, each tailored for a specific application and end use.

Explore our range of Thickeners

Nanofibrillated Cellulose

Wood-derived material consisting of fibrils with high aspect ratio: (5–20 nm wide and several microns long).

Xanthan Gum

Polysaccharide widely used as an effective and approved thickening agent and stabilizer for various food products.

Glucomannan

Water-soluble polysaccharide that gels at ambient conditions and increases the viscosity of a liquid making it an effective thickener.

Neutralizers and Buffers

Fast and easy dilution and neutralizing.

Using a solution with the optimal pH and isotonicity when reconstituting biomaterials is vital for successful cell culturing. Our reconstitution agents and buffers are optimized to make the reconstitution, dilution and neutralizing of biomaterials easy and fast.

Explore our range of Neutralizers and Buffers

Collagen Buffer

Developed to ease the neutralization process of CELLINK’s Coll 1 Lyophilizate, Coll 1 Solution, ColMA Lyophilizate, and ColMA Solution.

Reconstitution Agent P

Ideal for dissolving and diluting GelMA Lyophilizate and HAMA Lyophilizate for bioink formulation purposes.

Reconstitution Agent M

Ideal buffer for dissolving and diluting alginate and other charge-bearing polysaccharides.

Reconstitution agent A

Acidic solution ideal for dissolving and diluting CELLINK’s collagen biomaterials such as Coll1 Lyophilizate,

Crosslinking Agents and Photoinitiators

Keep bioinks intact and stable.

Crosslinking of your bioinks is vital for keeping them intact and stable during cell culture and analysis. The crosslinking agent is the ideal companion for any alginate-based bioink since it enables ionic crosslinking with calcium ions. Photoinitiators are used in combination with methacrylated biomaterials to enable photocuring by forming covalent bonds and are ideal for use with ColMA, GelMA and HAMA.

Explore our range of Crosslinking Agents and Photoinitiators

Irgacure 2959 Powder

Photoinitiator utilized for the polymerization of water-soluble polymeric materials, such as hydrogels and bioinks.

Crosslinking Agent

Our Crosslinking Agent contains 50 mM calcium chloride to crosslink bioinks containing alginate, for example CELLINK Bioink, GelXA and CELLINK A.

LAP Powder

Cytocompatible photoinitiator utilized for the polymerization of water-soluble polymeric materials.