Drug Delivery

Automating complex drug testing and delivery systems

Introduction

With changing medicines, increasingly complex therapeutic proteins and the advent of personalized therapies, more advanced ways to deliver these drugs are needed. This includes, for example, the controlled release of a drug at the right time and place. Many new therapeutic drugs or bioactive molecules hold tremendous potential as therapies; however, they often face solubility issues, instabilities during administration, lack bioavailability or can have unwanted off-target effects.

Nano- and micro-encapsulation of drugs is a growing field that offers solutions to many of the problems associated with drug delivery and is also showing potential for specific targeting of therapeutics, through surface modification techniques that promote binding to specific sites within the body. Additionally, sustained, triggered and extended release drug-delivery systems have been developed. At CELLINK, we provide a set of innovative tools that help you accelerate the development and testing of the next-generation drug-delivery systems.

Hydrogel Drug-Delivery Systems

Bioprinters can do more than print with cells, they can also be used for fabricating hydrogel drug encapsulation and extended-release technologies. The BIO X bioprinter offers a variety of printheads that are compatible with different hydrogels. Drugs and bioactives can be mixed within the hydrogels and printed in patterns such as large patches or micrometer-sized beads.

Light based bioprinters, such as the Lumen X and Holograph X offer even more precise control during fabrication; uniform micro-array particle patterns can be cured containing drugs with specific geometries such as rods, discs or spheres, as well as larger patches. In addition, our light-based bioprinters can be used to fabricate microfluidic organ-on-a-chip models, which in turn can be used to study perfusion of targeted drugs and particles in more physiologically relevant human models.

Light based bioprinters, such as the Lumen X and Holograph X offer even more precise control during fabrication, where uniform micro-array particle patterns can be cured containing drugs with specific geometries such as rods, discs, or spheres, as well as larger patches. In addition, our bioprinters can be used to fabricate microfluidic organ-on-a-chip models, which in turn can be used to study perfusion of targeted drugs and particles in more physiologically relevant human models.

Monitoring Drug-Delivery Activity in Real-Time

Evaluating Liver Toxicity in Bioprinted Mini Livers

High‐Throughput Screening of Cell Transfection Enhancers Using Miniaturized Droplet Microarrays

Author(s): Yanxi Liu Tina Tronser Ravindra Peravali Markus Reischl Pavel A. Levkin

Controlling Adult Stem Cell Behavior Using Nanodiamond-Reinforced Hydrogel: Implication in Bone Regeneration Therapy

Author(s): Pacelli, S., Maloney, R., Chakravarti, A. R., Whitlow, J., Basu, S., Modaresi, S., … & Paul, A. (2017).

University of Kansas

Related products

BIO X™

The most user-friendly bioprinter in the world thanks to its open system, intelligent and interchangeable printheads. Assists in developing complex tissue constructs, testing new drug compounds and streamline workflows in a range of application areas.

BIO X6™

The most flexible six-printhead bioprinting platform on the market and the preferred system for those ready to make history. With the BIO X6 in your lab, you can combine more materials, cells and tools — and get your results sooner — than ever before.

LUMEN X™

Enhancing applications such as microfluidics, cell-laden hydrogels and macroporous structures. Designed to print vasculature with biocompatible blue light, it offers advantages in achieving complex branching and tapering of vessels.

Holograph X™

Laser-based bioprinter able to recreate human physiology at sub-micrometer resolutions within minutes. Fully automated, it accepts any user-designed structure and laser prints transplantable 3D tissue scaffolds for research and therapeutic development.